Nutrition

GLP-1 semiglutide medications, muscle and bone loss

Like any clinician working in 21st century American healthcare, over the last 12 months, I've come in contact with an explosion of patients taking GLP-1 semiglutide medications. While those medications were initially labeled for diabetic control, the vast majority of cases presenting in my office are for weight loss. And like many colleagues in the integrated space, balancing the facts about the benefits of a medication addressing severe persistent medically dangerous obesity with known and unknown side effects has been a fine balancing act.

Behind closed doors, when colleagues and I candidly discuss our experience with patients taking this new class of medication, we all wonder when the proverbial other shoe will fall off. There has been an unbridled enthusiasm about the potential for those medication to help curb the scourge of chronic population obesity, but probably a bit of a vacuum when it comes to discussing all of the pros and cons of the prolonged use of a class of medication that historically had been reserved for the patient with poorly controlled diabetes. After 30 years in practice, you acquire a little bit of healthy cynicism when it comes to new treatments of any sort, knowing that some downfalls are not readily available during the "honeymoon" period of a launch that can take months to years to unfold.

There may be a bit of the proverbial shoe starting to drop based on the most recent article published in Lancet (1 of the top dogs of straightforward published medical research). The speed at which patients can lose weight, it turns out, is not all about tissue that you would want to shed. A whopping 3rd of the weight loss comes from lean muscle tissue. This is in contrast to nonmedically induced weight loss from calorie restriction and physical activity, which has a much better track record at preserving lean muscle mass. The latter is quite important for long-term weight maintenance, since muscle tissue is much more metabolically active at burning calories at rest, acting as a blood sugar buffer, among other things.

From a neuromusculoskeletal provider standpoint, the research article hit a bit of a raw nerve because of the implications for our treatment plan. I had already started to suspect that patients on long-term GLP-1 exhibiting significant weight loss were also presenting with decreased overall muscle tone, bulk and endurance, complicating the stabilization phase of the typical spinal and extremity pain that were trying to treat. Another aspect of the rapid weight loss involving muscle tissue that is not brought up by Lancet but is a big concern to me is the concurrent potential impact on decreased bone mass. Lean muscle mass loss and bone loss tend to go hand in hand during significant weight loss.

The research article has reminded me of the importance of reviewing with patients 3 important mitigating strategies with patients on long-term GLP-1:

incorporate a sufficient amount of protein in the diet while on the medication, defined as a minimum of half a gram of protein per pound of body weight. This means that a 200 pound adult would need 100 g of protein. You have to be really intentional about reaching that goal every day through combination of protein dense foods with every meal, and potentially supplemental protein.

Engage in resistance training to 3 times a week that is sufficient to stimulate muscle growth. Just doing activities of daily living and walking is not going to preserve muscle mass.

Consider adding a good bone building support supplement, which is going to contain a combination of bioavailable calcium, magnesium, other bone building minerals, vitamin D3 and vitamin K 2.

Revisiting the best Vit D supplementation for the winter months

It feels a little paradoxical to be adding this blog while the temperature is scheduled to hit the mid 80s today, however the weather forecast is calling for a temperature cliff at the end of the week, and my Windows automatic photo update posted a beautiful snowy landscape upon firing my machine this morning. I take that as a sign from the universe that it's time to talk about a topic that will very soon affect us all.

The topic of vitamin D levels in health and disease has waned a little bit in popularity since its peak of research around 2010, although it did enjoy a resurgence during the Covid pandemic. The research has really been all over the map for laypeople, and even at times confusing for healthcare professionals, until you dig a little bit deeper into the details of the study such as the type of biomarker measured, the target population, etc.

I recently polished up on the latest research and recommendation from a couple of pretty good trusted nutritional sources to see what a commonsense consensus would be. Here are my highlighted suggestions:

1st of all, vitamin D metabolism is extremely variable among different people so generic recommendations about intake are only going to go so far. Ideally you should get your vitamin D level tested. It's typically lowest in the spring, and highest at the end of the summer. This is assuming that humans follow an ancestral pattern of having outdoors skin exposure for vitamin D manufacturing for the summer, which is not always true of our modern lifestyle and individual lives. I recommend getting it tested at both of these peaks. Testing can be done through a variety of manners, including traditional testing through primary care, through Labcorp/Quest direct, or through home kits using blood spot finger prick method. (It's beyond this blog to talk about resources, but patients can contact the office and schedule a consult for that separately).

Vitamin D absorption is impacted by digestive issues especially along the biliary tree since vitamin D is a fat-soluble vitamin, as well as medications that impact lipid absorption and metabolism (especially certain cholesterol medications). Vitamin D need is also increased by certain illnesses. So you really need to look at your own individual factors when trying to eyeball your needs.

As far as ideal blood levels, you'll see different schools of thoughts. Some outfits recommending very high levels of vitamin D3 above 50 and sometimes close to 80, and some people making much lower recommendations. Looking at the more recent research I think the average population does best between 30 and 50. This would be in line with what we have historically known of traditional human population with levels never exceeding 46 with whole foods diet and outdoor sun exposure. However there are subpopulation of peoples with special health needs, especially autoimmune, that may do better with a therapeutic goal above 50. However those people should always be working with a healthcare professional to ensure that those high levels of vitamin D are not causing secondary problems.

Vitamin D is part of a group of fat-soluble vitamins that are finally regulated as a whole, and depend on each other for the proper management of calcium deposition in bone and soft tissues. Probably the strongest recommendation update I am pushing forward now would be to not routinely supplement vitamin D alone, but rather look at a minimum combination of vitamin D3/K2/A in the right ratios. This will prevent some unwanted effects of over dominant vitamin D3 among fat-soluble vitamin, which could negatively impact the deposition of calcium into soft tissues rather than bone. This is especially true in patients with cardiovascular disease and osteoporosis, and with patients who have to limits the intake of dairy products (which tends to provide the vitamin K2). Professional brands of nutritional supplements have started reformulating their fat-soluble vitamins along those lines with several good options both in gel caps and liquid forms.

Food reactivity testing just got easier

IgG food reaction testing has been a useful test in our practice for many moons. The immune inflammatory cascade triggered by an antibody based reaction to foods can impact a variety of tissues and system well beyond the GI: chronic soft tissue pain, mood disorders, skin outbreaks, chronic rhinitis, fatigue and poor immune resistance just to name a few. Up until recently there have been some logistical barriers to complete the test, namely the need to get a regular blood draw. Genova had recently expanded their offerings to include a home blood spot option for the routine 70 antigen food IgG panel. It only requires a finger prick and collection of blood spot onto a paper blot that is mailed directly to the lab.